Aldudo, J., M. J. Bullido, et al. (1998). "Missense mutation E318G of the presenilin-1 gene appears to be a nonpathogenic polymorphism." Ann Neurol 44(6): 985-6.
Ancolio, K., P. Marambaud, et al. (1997). "Alpha-secretase-derived product of beta-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease." J Neurochem 69(6): 2494-9.
Annaert, W. and B. De Strooper (1999). "Presenilins: molecular switches between proteolysis and signal transduction." Trends Neurosci 22(10): 439-43.
Annaert, W. and B. De Strooper (2002). "A cell biological perspective on Alzheimer's disease." Annu Rev Cell Dev Biol 18: 25-51.
Annaert, W. G., C. Esselens, et al. (2001). "Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins." Neuron 32(4): 579-89.
Arawaka, S., H. Hasegawa, et al. (2002). "The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein." J Neurochem 83(5): 1065-71.
Armogida, M., A. Petit, et al. (2001). "Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts." Nat Cell Biol 3(11): 1030-3.
Basi, G., N. Frigon, et al. (2003). "Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells." J Biol Chem 278(34): 31512-20.
Beher, D., J. D. Wrigley, et al. (2001). "Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology." J Biol Chem 276(48): 45394-402.
Beher, D., J. D. Wrigley, et al. (2002). "Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity." J Neurochem 82(3): 563-75.
Benjannet, S., A. Elagoz, et al. (2001). "Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production." J Biol Chem 276(14): 10879-87.
Bennett, B. D., P. Denis, et al. (2000). "A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase." J Biol Chem 275(48): 37712-7.
Berchtold, N. C. and C. W. Cotman (1998). "Evolution in the conceptualization of dementia and Alzheimer's disease: Greco-Roman period to the 1960s." Neurobiol Aging 19(3): 173-89.
Berezovska, O., C. Jack, et al. (2000). "Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling." J Neurochem 75(2): 583-93.
Boller, F. and M. M. Forbes (1998). "History of dementia and dementia in history: an overview." J Neurol Sci 158(2): 125-33.
Borchelt, D. R., G. Thinakaran, et al. (1996). "Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo." Neuron 17(5): 1005-13.
Boulianne, G. L., I. Livne-Bar, et al. (1997). "Cloning and characterization of the Drosophila presenilin homologue." Neuroreport 8(4): 1025-9.
Cai, D., J. Y. Leem, et al. (2003). "Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein." J Biol Chem 278(5): 3446-54.
Campbell, W. A., M. K. Iskandar, et al. (2002). "Endoproteolysis of presenilin in vitro: inhibition by gamma-secretase inhibitors." Biochemistry 41(10): 3372-9.
Campbell, W. A., M. L. Reed, et al. (2003). "Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase." J Neurochem 85(6): 1563-74.
Capell, A., J. Grunberg, et al. (1998). "The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex." J Biol Chem 273(6): 3205-11.
Capell, A., H. Steiner, et al. (2000). "Maturation and pro-peptide cleavage of beta-secretase." J Biol Chem 275(40): 30849-54.
Cervantes, S., R. Gonzalez-Duarte, et al. (2001). "Homodimerization of presenilin N-terminal fragments is affected by mutations linked to Alzheimer's disease." FEBS Lett 505(1): 81-6.
Chen, F., G. Yu, et al. (2001). "Nicastrin binds to membrane-tethered Notch." Nat Cell Biol 3(8): 751-4.
Citron, M., C. B. Eckman, et al. (1998). "Additive effects of PS1 and APP mutations on secretion of the 42- residue amyloid beta-protein." Neurobiol Dis 5(2): 107-16.
Citron, M., D. Westaway, et al. (1997). "Mutant presenilins of Alzheimer's disease increase production of 42- residue amyloid beta-protein in both transfected cells and transgenic mice." Nat Med 3(1): 67-72.
Cruts, M., B. Dermaut, et al. (2001). "Amyloid beta secretase gene (BACE) is neither mutated in nor associated with early-onset Alzheimer's disease." Neurosci Lett 313(1-2): 105-7.
Davis, J. A., S. Naruse, et al. (1998). "An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos." Neuron 20(3): 603-9.
De Strooper, B. (2003). "Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active gamma- Secretase Complex." Neuron 38(1): 9-12.
De Strooper, B., M. Beullens, et al. (1997). "Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins." J Biol Chem 272(6): 3590-8.
De Strooper, B., P. Saftig, et al. (1998). "Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein." Nature 391(6665): 387-90.
De Strooper, B. and J. Woodgett (2003). "Alzheimer's disease: Mental plaque removal." Nature 423(6938): 392-3.
De Strooper, B., Annaert, W. et al. (1999) A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature Apr 8;398(6727):518-22
Dingwall, C. (2001). "Spotlight on BACE: the secretases as targets for treatment in Alzheimer disease." J Clin Invest 108(9): 1243-6.
Doan, A., G. Thinakaran, et al. (1996). "Protein topology of presenilin 1." Neuron 17(5): 1023-30.
Edbauer, D., E. Winkler, et al. (2003). "Reconstitution of gamma-secretase activity." Nat Cell Biol 5(5): 486-8.
Esler, W. P., W. T. Kimberly, et al. (2000). "Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1." Nat Cell Biol 2(7): 428-34.
Esler, W. P., W. T. Kimberly, et al. (2002). "Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate." Proc Natl Acad Sci U S A 99(5): 2720-5.
Evin, G., D. Le Brocque, et al. (2000). "Presenilin I expression in yeast lowers secretion of the amyloid precursor protein." Neuroreport 11(2): 405-8.
Evin, G. and A. Weidemann (2002). "Biogenesis and metabolism of Alzheimer's disease Abeta amyloid peptides." Peptides 23(7): 1285-97.
Farmery, M. R., L. O. Tjernberg, et al. (2003). "Partial purification and characterization of gamma-secretase from post-mortem human brain." J Biol Chem 278(27): 24277-84.
Farzan, M., C. E. Schnitzler, et al. (2000). "BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein." Proc Natl Acad Sci U S A 97(17): 9712-7.
Fassbender, K., C. Masters, et al. (2001). "Alzheimer's disease: molecular concepts and therapeutic targets." Naturwissenschaften 88(6): 261-7.
Fluhrer, R., G. Multhaup, et al. (2003). "Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation." J Biol Chem 278(8): 5531-8.
Francis, R., G. McGrath, et al. (2002). "aph-1 and pen-2 are required for Notch pathway signaling, gamma- secretase cleavage of betaAPP, and presenilin protein accumulation." Dev Cell 3(1): 85-97.
Fraser, P. E., D. S. Yang, et al. (2000). "Presenilin structure, function and role in Alzheimer disease." Biochim Biophys Acta 1502(1): 1-15.
Fukumoto, H., B. S. Cheung, et al. (2002). "Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease." Arch Neurol 59(9): 1381-9.
Goate, A., M. C. Chartier-Harlin, et al. (1991). "Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease." Nature 349(6311): 704-6.
Goate, A. M. (1997). "Molecular genetics of Alzheimer's disease." Geriatrics 52 Suppl 2: S9-12.
Godin, C., Auclair, A., Ferland, M., Hébert, S.S., Carreau, M., Levesque, G. (2003). "Presenilin-1 is indirectly implicated in Notch1 cleavage." J. Neurochem. Aug 26;14(12):1613-6.
Gottfries, C. G. (1988). "Alzheimer's disease. A critical review." Compr Gerontol [C] 2(1): 47-62.
Gouldson, P. R., C. Higgs, et al. (2000). "Dimerization and domain swapping in G-protein-coupled receptors: a computational study." Neuropsychopharmacology 23(4 Suppl): S60-77.
Gu, Y., F. Chen, et al. (2003). "APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes." J Biol Chem 278(9): 7374-80.
Guo, Q., K. Furukawa, et al. (1996). "Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide." Neuroreport 8 (1): 379-83.
Haass, C. and B. De Strooper (1999). "The presenilins in Alzheimer's disease--proteolysis holds the key." Science 286(5441): 916-9.
Haass, C., C. A. Lemere, et al. (1995). "The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway." Nat Med 1(12): 1291-6.
Haass, C. and H. Steiner (2002). "Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases." Trends Cell Biol 12(12): 556-62.
Hardy, J., K. Duff, et al. (1998). "Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau." Nat Neurosci 1(5): 355-8.
Hardy, J. and D. J. Selkoe (2002). "The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics." Science 297(5580): 353-6.
Hattori, C., M. Asai, et al. (2002). "BACE1 interacts with nicastrin." Biochem Biophys Res Commun 293(4): 1228-32.
Hébert, S. S., V. Bourdages, et al. (2003). "Presenilin-1 interacts directly with the beta-site amyloid protein precursor cleaving enzyme (BACE1)." Neurobiol Dis 13(3): 238-45.
Hébert, S. S., C. Godin, et al. (2003a). "Oligomerization of human presenilin-1 fragments." FEBS Lett 550(1-3): 30-4.
Hébert, S. S., C. Godin, et al. (2003b). "Dimerization of presenilin-1 in vivo: suggestion of novel regulatory mechanisms leading to higher order complexes." Biochem Biophys Res Commun 301(1): 119-26.
Higgins, G. A., C. H. Large, et al. (1997). "Apolipoprotein E and Alzheimer's disease: a review of recent studies." Pharmacol Biochem Behav 56(4): 675-85.
Holsinger, R. M., C. A. McLean, et al. (2002). "Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease." Ann Neurol 51(6): 783-6.
Honda, T., K. Yasutake, et al. (1999). "Dual roles of proteasome in the metabolism of presenilin 1." J Neurochem 72(1): 255-61.
Howlett, D. R., D. L. Simmons, et al. (2000). "In search of an enzyme: the beta-secretase of Alzheimer's disease is an aspartic proteinase." Trends Neurosci 23(11): 565-70.
Hu, Y. and M. E. Fortini (2003). "Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex." J Cell Biol 161(4): 685-90.
Huse, J. T. and R. W. Doms (2000). "Closing in on the amyloid cascade: recent insights into the cell biology of Alzheimer's disease." Mol Neurobiol 22(1-3): 81-98.
Huse, J. T., K. Liu, et al. (2002). "Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain." J Biol Chem 277(18): 16278-84.
Hussain, I., D. Powell, et al. (1999). "Identification of a novel aspartic protease (Asp 2) as beta-secretase." Mol Cell Neurosci 14(6): 419-27.
Janicki, S. M., S. M. Stabler, et al. (2000). "Familial Alzheimer's disease presenilin-1 mutants potentiate cell cycle arrest." Neurobiol Aging 21 (6): 829-36.
Jarrett, J. T., E. P. Berger, et al. (1993). "The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease." Biochemistry 32(18): 4693-7.
Jarrett, J. T. and P. T. Lansbury, Jr. (1993). "Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?" Cell 73(6): 1055-8.
Jorm, A. F. (1997). "Alzheimer's disease: risk and protection." Med J Aust 167(8): 443-6.
Kaether, C., S. Lammich, et al. (2002). "Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane." J Cell Biol 158(3): 551-61.
Kamal, A., A. Almenar-Queralt, et al. (2001). "Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP." Nature 414(6864): 643-8.
Kametaka, S., M. Shibata, et al. (2003). "Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))." J Biol Chem 278(17): 15239-45.
Kang, J., H. G. Lemaire, et al. (1987). "The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor." Nature 325(6106): 733-6.
Kim, S. H., T. Ikeuchi, et al. (2003). "Regulated hyperaccumulation of presenilin-1 and the "gamma -secretase" complex: Evidence for differential intramembranous processing of transmembrane substrates." J Biol Chem.
Kim, S. S., Y. M. Choi, et al. (1997). "Lack of interactions between amyloid precursor protein and hydrophilic domains of presenilin 1 and 2 using the yeast two hybrid system." J Mol Neurosci 9(1): 49-54.
Kimberly, W. T., M. J. LaVoie, et al. (2003). "{gamma}-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2." Proc Natl Acad Sci U S A 100(11): 6382-6387.
Kimberly, W. T., W. Xia, et al. (2000). "The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation." J Biol Chem 275(5): 3173-8.
King, S. A. and E. J. Sorscher (2000). "R-domain interactions with distal regions of CFTR lead to phosphorylation and activation." Biochemistry 39(32): 9868-75.
Kinoshita, A., H. Fukumoto, et al. (2003). "Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes." J Cell Sci 116(Pt 16): 3339-46.
Kirk, K. L. (2000). "New paradigms of CFTR chloride channel regulation." Cell Mol Life Sci 57(4): 623-34.
Kitaguchi, N., Y. Takahashi, et al. (1988). "Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity." Nature 331(6156): 530-2.
Kitazume, S., T. C. Saido, et al. (2002). "[Identification of a novel substrate of Alzheimer's beta-secretase: beta-secretase dependent cleavage of alpha 2,6 sialyltransferase]." Seikagaku 74(9): 1180-3.
Kitazume, S., Y. Tachida, et al. (2001). "Alzheimer's beta-secretase, beta-site amyloid precursor protein- cleaving enzyme, is responsible for cleavage secretion of a Golgi- resident sialyltransferase." Proc Natl Acad Sci U S A 98(24): 13554-9.
Komano, H., S. Sudoh, et al. (1999). "Implications of presenilin 1 mutations in Alzheimer's disease." Mech Ageing Dev 107(3): 281-98.
Kovacs, D. M., H. J. Fausett, et al. (1996). "Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells." Nat Med 2(2): 224-9.
Kowalska, A. (2003). "Amyloid precursor protein gene mutations responsible for early-onset autosomal dominant Alzheimer's disease." Folia Neuropathol 41(1): 35-40.
Lah, J. J., C. J. Heilman, et al. (1997). "Light and electron microscopic localization of presenilin-1 in primate brain." J Neurosci 17(6): 1971-80.
Lahiri, D. K., M. R. Farlow, et al. (2003). "A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease." Curr Drug Targets 4(2): 97-112.
LaVoie, M. J., P. C. Fraering, et al. (2003). "Assembly of the gamma -secretase complex involves early formation of an intermediate sub-complex of Aph-1 and Nicastrin." J Biol Chem.
LaVoie, M. J. and D. J. Selkoe (2003). "The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments." J Biol Chem 278(36): 34427-37.
Lee, H. J., K. M. Jung, et al. (2002). "Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4." J Biol Chem 277(8): 6318-23.
Lee, M. K., D. R. Borchelt, et al. (1997). "Hyperaccumulation of FAD-linked presenilin 1 variants in vivo." Nat Med 3(7): 756-60.
Lee, S. F., S. Shah, et al. (2002). "Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch." J Biol Chem 277(47): 45013-9.
Lee, S. P., Z. Xie, et al. (2000). "Oligomerization of dopamine and serotonin receptors." Neuropsychopharmacology 23(4 Suppl): S32-40.
Leem, J. Y., C. A. Saura, et al. (2002). "A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface." Neurobiol Dis 11(1): 64-82.
Leem, J. Y., S. Vijayan, et al. (2002). "Presenilin 1 is required for maturation and cell surface accumulation of nicastrin." J Biol Chem 277(21): 19236-40.
Lehmann, S., R. Chiesa, et al. (1997). "Evidence for a six-transmembrane domain structure of presenilin 1." J Biol Chem 272(18): 12047-51.
Levesque, G., G. Yu, et al. (1999). "Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin." J Neurochem 72(3): 999-1008.
Levitan, D. and I. Greenwald (1995). "Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene." Nature 377(6547): 351-4.
Levitan, D., J. Lee, et al. (2001). "PS1 N- and C-terminal fragments form a complex that functions in APP processing and Notch signaling." Proc Natl Acad Sci U S A 98(21): 12186-90.
Li, J., M. Xu, et al. (1997). "Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation." Cell 90(5): 917-27.
Li, X. and I. Greenwald (1996). "Membrane topology of the C. elegans SEL-12 presenilin." Neuron 17(5): 1015-21.
Li, X. and I. Greenwald (1998). "Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins." Proc Natl Acad Sci U S A 95(12): 7109-14.
Li, Y. M., M. T. Lai, et al. (2000). "Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state." Proc Natl Acad Sci U S A 97(11): 6138-43.
Lichtenthaler, S. F., D. I. Dominguez, et al. (2003). "The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1." J Biol Chem.
Ling, Y., K. Morgan, et al. (2003). "Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer's disease." Int J Biochem Cell Biol 35(11): 1505-35.
Liu, H. C., S. J. Leu, et al. (2003). "The association of beta-site APP cleaving enzyme (BACE) C786G polymorphism with Alzheimer's disease." Brain Res 961(1): 88-91.
Liu, K., R. W. Doms, et al. (2002). "Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression." Biochemistry 41(9): 3128-36.
Lomize, A. L., I. D. Pogozheva, et al. (1999). "Structural organization of G-protein-coupled receptors." J Comput Aided Mol Des 13(4): 325-53.
Lullau, E., A. Kanttinen, et al. (2003). "Comparison of batch and perfusion culture in combination with pilot-scale expanded bed purification for the production of soluble recombinant beta-secretase." Biotechnol Prog 19(1): 37-44.
Luo, W. J., H. Wang, et al. (2003). "PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1." J Biol Chem 278(10): 7850-4.
Luo, Y., B. Bolon, et al. (2001). "Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation." Nat Neurosci 4(3): 231-2.
Marambaud, P., J. Shioi, et al. (2002). "A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions." Embo J 21(8): 1948-56.
Mattson, M. P., S. L. Chan, et al. (2001). "Presenilin mutations and calcium signaling defects in the nervous and immune systems." Bioessays 23(8): 733-44.
May, P., Y. K. Reddy, et al. (2002). "Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain." J Biol Chem 277(21): 18736-43.
Medina, M. and C. G. Dotti (2003). "RIPped out by presenilin-dependent gamma-secretase." Cell Signal 15(9): 829-41.
Murakami, D., I. Okamoto, et al. (2003). "Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44." Oncogene 22(10): 1511-6.
Murphy, T., A. Yip, et al. (2001). "The BACE gene: genomic structure and candidate gene study in late-onset Alzheimer's disease." Neuroreport 12(3): 631-4.
Nakai, T., A. Yamasaki, et al. (1999). "Membrane topology of Alzheimer's disease-related presenilin 1. Evidence for the existence of a molecular species with a seven membrane-spanning and one membrane-embedded structure." J Biol Chem 274(33): 23647-58.
Nicolaou, M., Y. Q. Song, et al. (2001). "Mutations in the open reading frame of the beta-site APP cleaving enzyme (BACE) locus are not a common cause of Alzheimer's disease." Neurogenetics 3(4): 203-6.
Nunan, J. and D. H. Small (2002). "Proteolytic processing of the amyloid-beta protein precursor of Alzheimer's disease." Essays Biochem 38: 37-49.
Nyabi, O., M. Bentahir, et al. (2003). "Presenilins mutated at Asp257 or Asp385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin." J Biol Chem.
Okochi, M., K. Ishii, et al. (1997). "Proteolytic processing of presenilin-1 (PS-1) is not associated with Alzheimer's disease with or without PS-1 mutations." FEBS Lett 418(1-2): 162-6.
Pasternak, S. H., R. D. Bagshaw, et al. (2003). "Presenilin, Nicastrin and Beta-Amyloid Production in the Endosomal/ Lysosomal System: Toward a Unifying Model of Alzheimer's Disease." J Biol Chem.
Petanceska, S. S., M. Seeger, et al. (2000). "Mutant presenilin 1 increases the levels of Alzheimer amyloid beta- peptide Abeta42 in late compartments of the constitutive secretory pathway." J Neurochem 74(5): 1878-84.
Pitsi, D., P. Kienlen-Campard, et al. (2002). "Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells." J Neurochem 83(2): 390-9.
Podlisny, M. B., M. Citron, et al. (1997). "Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue." Neurobiol Dis 3(4): 325-37.
Qian, S., P. Jiang, et al. (1998). "Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression." Neuron 20(3): 611-7.
Ratovitski, T., H. H. Slunt, et al. (1997). "Endoproteolytic processing and stabilization of wild-type and mutant presenilin." J Biol Chem 272(39): 24536-41.
Ray, W. J., M. Yao, et al. (1999). "Evidence for a physical interaction between presenilin and Notch." Proc Natl Acad Sci U S A 96(6): 3263-8.
Richter, C., T. Tanaka, et al. (1998). "Mechanism of activation of the gastric aspartic proteinases: pepsinogen, progastricsin and prochymosin." Biochem J 335 ( Pt 3): 481-90.
Robakis, N. K., N. Ramakrishna, et al. (1987). "Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides." Proc Natl Acad Sci U S A 84(12): 4190-4.
Roberds, S. L., J. Anderson, et al. (2001). "BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics." Hum Mol Genet 10(12): 1317-24.
Rocchi, A., S. Pellegrini, et al. (2003). "Causative and susceptibility genes for Alzheimer's disease: a review." Brain Res Bull 61(1): 1-24.
Rogaev, E. I., R. Sherrington, et al. (1995). "Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene." Nature 376(6543): 775-8.
Russo, C., G. Schettini, et al. (2000). "Presenilin-1 mutations in Alzheimer's disease." Nature 405(6786): 531-2.
Salib, E. (2000). "Risk factors for Alzheimer's disease." Elder Care 11(10): 12-5.
Sato, N., K. Imaizumi, et al. (2001). "Increased production of beta-amyloid and vulnerability to endoplasmic reticulum stress by an aberrant spliced form of presenilin 2." J Biol Chem 276(3): 2108-14.
Saura, C. A., T. Tomita, et al. (1999). "Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing." J Biol Chem 274(20): 13818-23.
Scheuner, D., C. Eckman, et al. (1996). "Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease." Nat Med 2(8): 864-70.
Scholefield, Z., E. A. Yates, et al. (2003). "Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's {beta}-secretase." J Cell Biol 163(1): 97-107.
Schoneberg, T., G. Schultz, et al. (1999). "Structural basis of G protein-coupled receptor function." Mol Cell Endocrinol 151(1-2): 181-93.
Schulz, J. G., W. Annaert, et al. (2003). "Syndecan 3 intramembrane proteolysis is presenilin/gamma -secretase-dependent and modulates cytosolic signaling." J Biol Chem.
Selkoe, D. J. (1999). "Translating cell biology into therapeutic advances in Alzheimer's disease." Nature 399(6738 Suppl): A23-31.
Selkoe, D. J. (2000). "Notch and presenilins in vertebrates and invertebrates: implications for neuronal development and degeneration." Curr Opin Neurobiol 10(1): 50-7.
Selkoe, D. J. (2001). "Alzheimer's disease: genes, proteins, and therapy." Physiol Rev 81(2): 741-66.
Selkoe, D. J. and M. S. Wolfe (2000). "In search of gamma-secretase: presenilin at the cutting edge." Proc Natl Acad Sci U S A 97(11): 5690-2.
Shen, J., R. T. Bronson, et al. (1997). "Skeletal and CNS defects in Presenilin-1-deficient mice." Cell 89(4): 629-39.
Sherrington, R., S. Froelich, et al. (1996). "Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant." Hum Mol Genet 5(7): 985-8.
Sherrington, R., E. I. Rogaev, et al. (1995). "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease." Nature 375(6534): 754-60.
Shi, X. P., E. Chen, et al. (2001). "The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain." J Biol Chem 276(13): 10366-73.
Shi, X. P., K. Tugusheva, et al. (2003). "{beta}-Secretase Cleavage at Amino Acid Residue 34 in the Amyloid {beta} Peptide Is Dependent upon {gamma}-Secretase Activity." J Biol Chem 278(23): 21286-21294.
Sinha, S. (2002). "The role of beta-amyloid in Alzheimer's disease." Med Clin North Am 86(3): 629-39.
Sinha, S., J. P. Anderson, et al. (1999). "Purification and cloning of amyloid precursor protein beta-secretase from human brain." Nature 402(6761): 537-40.
Sinha, S. and I. Lieberburg (1999). "Cellular mechanisms of beta-amyloid production and secretion." Proc Natl Acad Sci U S A 96(20): 11049-53.
Small, D. H. (2001). "The role of presenilins in gamma-secretase activity: catalyst or cofactor?" J Neurochem 76(6): 1612-4.
Sommer, B. (2002). "Alzheimer's disease and the amyloid cascade hypothesis: ten years on." Curr Opin Pharmacol 2(1): 87-92.
Song, S., M. Ohba, et al. (2000). "Proteolytic processing and degradation of human presenilin-1 expressed in yeast." Neurosci Lett 282(1-2): 65-8.
Steiner, H., A. Capell, et al. (1998). "Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation." J Biol Chem 273(48): 32322-31.
Steiner, H. and C. Haass (2000). "Intramembrane proteolysis by presenilins." Nat Rev Mol Cell Biol 1(3): 217-24.
Steiner, H., E. Winkler, et al. (2002). "PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin." J Biol Chem 277(42): 39062-5.
Steinhilb, M. L., R. S. Turner, et al. (2002). "ELISA analysis of beta-secretase cleavage of the Swedish amyloid precursor protein in the secretory and endocytic pathways." J Neurochem 80(6): 1019-28.
Sudoh, S., Y. Kawamura, et al. (1998). "Presenilin 1 mutations linked to familial Alzheimer's disease increase the intracellular levels of amyloid beta-protein 1-42 and its N-terminally truncated variant(s) which are generated at distinct sites." J Neurochem 71(4): 1535-43.
Takasugi, N., T. Tomita, et al. (2003). "The role of presenilin cofactors in the gamma-secretase complex." Nature 422(6930): 438-41.
Tandon, A. and P. Fraser (2002). "The presenilins." Genome Biol 3(11): reviews3014.
Tekirian, T. L. (2001). "Commentary: Abeta N- Terminal Isoforms: Critical contributors in the course of AD pathophysiology." J Alzheimers Dis 3(2): 241-248.
Thinakaran, G. (2001). "Metabolism of presenilins." J Mol Neurosci 17(2): 183-92.
Thinakaran, G., D. R. Borchelt, et al. (1996). "Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo." Neuron 17(1): 181-90.
Thinakaran, G., J. B. Regard, et al. (1998). "Stable association of presenilin derivatives and absence of presenilin interactions with APP." Neurobiol Dis 4(6): 438-53.
Tomita, T., R. Takikawa, et al. (1999). "C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin." J Neurosci 19(24): 10627-34.
Tomita, T., T. Watabiki, et al. (2001). "The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins." J Biol Chem 276(35): 33273-81.
Torreilles, F. and J. Touchon (2002). "Pathogenic theories and intrathecal analysis of the sporadic form of Alzheimer's disease." Prog Neurobiol 66(3): 191-203.
Tyler, S. J., D. Dawbarn, et al. (2002). "alpha- and beta-secretase: profound changes in Alzheimer's disease." Biochem Biophys Res Commun 299(3): 373-6.
Van Gassen, G. and W. Annaert (2003). "Amyloid, presenilins, and Alzheimer's disease." Neuroscientist 9(2): 117-26.
Van Gassen, G., C. De Jonghe, et al. (1999). "Alzheimer's disease associated presenilin 1 interacts with HC5 and ZETA, subunits of the catalytic 20S proteasome." Neurobiol Dis 6(5): 376-91.
Vassar, R. (2001). "The beta-secretase, BACE: a prime drug target for Alzheimer's disease." J Mol Neurosci 17(2): 157-70.
Vassar, R., B. D. Bennett, et al. (1999). "Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE." Science 286(5440): 735-41.
Walsh, D. M., J. V. Fadeeva, et al. (2003). "gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins." Biochemistry 42(22): 6664-73.
Walter, J., A. Capell, et al. (1996). "The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum." Mol Med 2(6): 673-91.
Wilson, C. A., R. W. Doms, et al. (2002). "Presenilins are not required for Abeta42 production in the early secretory pathway." Nat Neurosci 29: 29.
Wolfe, M. S. (2001). "gamma-Secretase inhibitors as molecular probes of presenilin function." J Mol Neurosci 17(2): 199-204.
Wolfe, M. S. (2003). "{gamma}-Secretase--Intramembrane Protease with a Complex." Sci Aging Knowl Environ 2003(11): PE7.
Wolfe, M. S., W. Xia, et al. (1999). "Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity." Nature 398(6727): 513-7.
Wolozin, B., P. Alexander, et al. (1998). "Regulation of apoptosis by presenilin 1." Neurobiol Aging 19(1 Suppl): S23-7.
Wong, P. C., H. Zheng, et al. (1997). "Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm." Nature 387(6630): 288-92.
Xia, W. (2001). "Amyloid metabolism and secretases in Alzheimer's disease." Curr Neurol Neurosci Rep 1 (5): 422-7.
Xia, W. and M. S. Wolfe (2003). "Intramembrane proteolysis by presenilin and presenilin-like proteases." J Cell Sci 116(Pt 14): 2839-44.
Yan, R., M. J. Bienkowski, et al. (1999). "Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity." Nature 402(6761): 533-7.
Yan, R., P. Han, et al. (2001). "The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate." J Biol Chem 276(39): 36788-96.
Yang, D. S., A. Tandon, et al. (2002). "Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins." J Biol Chem 277(31): 28135-42.
Yu, G., F. Chen, et al. (1998). "The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin." J Biol Chem 273(26): 16470-5.
Yu, G., M. Nishimura, et al. (2000). "Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing." Nature 407(6800): 48-54.
Zhang, H., H. Komano, et al. (1994). "Proteolytic processing and secretion of human beta-amyloid precursor protein in yeast. Evidence for a yeast secretase activity." J Biol Chem 269(45): 27799-802.
Zhang, J., D. E. Kang, et al. (1998). "Subcellular distribution and turnover of presenilins in transfected cells." J Biol Chem 273(20): 12436-42.
Zhang, Z., P. Nadeau, et al. (2000). "Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1." Nat Cell Biol 2(7): 463-5.
Zhou, Y., W. Zhang, et al. (2002). "Presenilin-1 protects against neuronal apoptosis caused by its interacting protein PAG." Neurobiol Dis 9(2): 126-38.